Statistical Approach to Incorporating Experimental Variability into a Mathematical Model of the Voltage-Gated Na<sup>+</sup> Channel and Human Atrial Action Potential

Statistical Approach to Incorporating Experimental Variability into a Mathematical Model of the Voltage-Gated Na<sup>+</sup> Channel and Human Atrial Action Potential

The voltage-gated Na<sup>+</sup> channel Na<sub>v</sub>1.5 is critical for normal cardiac myocyte excitability. Mathematical models have been widely used to study Na<sub>v</sub>1.5 function and link to a range of cardiac arrhythmias. There is growing appreciation...

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Bibliographic Details
Main Authors: Daniel Gratz, Alexander J Winkle, Seth H Weinberg, Thomas J Hund
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Cells
Subjects:
computational model
electrophysiology
atrial fibrillation
arrhythmia
Bayesian statistics
voltage-gated sodium channel
Online Access:https://www.mdpi.com/2073-4409/10/6/1516

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