Libertellenone H, a Natural Pimarane Diterpenoid, Inhibits Thioredoxin System and Induces ROS-Mediated Apoptosis in Human Pancreatic Cancer Cells

Libertellenone H, a Natural Pimarane Diterpenoid, Inhibits Thioredoxin System and Induces ROS-Mediated Apoptosis in Human Pancreatic Cancer Cells

Libertellenone H (LH), a marine-derived pimarane diterpenoid isolated from arctic fungus <i>Eutypella</i> sp. D-1, has shown effective cytotoxicity on a range of cancer cells. The present study is to explore the anticancer effect of LH on human pancreatic cancer cells and to investigate...

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Bibliographic Details
Main Authors: Weirui Zhang, Yuping Zhu, Haobing Yu, Xiaoyu Liu, Binghua Jiao, Xiaoling Lu
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Molecules
Subjects:
Libertellenone H
pancreatic cancer
ROS
Trx system
apoptosis
Online Access:https://www.mdpi.com/1420-3049/26/2/315

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