Current Advances on the Important Roles of Enhancer RNAs in Gene Regulation and Cancer

Revealing the gene regulation networks governing cancer initiation and development is necessary while it remains uncompleted. In recent years, enhancers have been reported to be widely transcribed, resulting in the generation of enhancer RNAs (eRNAs). Previous studies have reported that eRNAs are a...

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Main Authors:	Yuhan Liu, Mengting Ding, Qunjun Gao, Anbang He, Yuchen Liu, Hongbing Mei
Format:	Article
Language:	English
Published:	Hindawi Limited 2018-01-01
Series:	BioMed Research International
Online Access:	http://dx.doi.org/10.1155/2018/2405351

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spelling	doaj-44101dba408447c1bcdc781d7537dc972020-11-24T21:41:31ZengHindawi LimitedBioMed Research International2314-61332314-61412018-01-01201810.1155/2018/24053512405351Current Advances on the Important Roles of Enhancer RNAs in Gene Regulation and CancerYuhan Liu0Mengting Ding1Qunjun Gao2Anbang He3Yuchen Liu4Hongbing Mei5Department of Urology, Shenzhen Second People’s Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen 518000, ChinaDepartment of Urology, Shenzhen Second People’s Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen 518000, ChinaDepartment of Urology, Shenzhen Second People’s Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen 518000, ChinaDepartment of Urology, Peking University First Hospital, The Institute of Urology, Peking University, National Urological Cancer Centre, Beijing 100034, ChinaDepartment of Urology, Shenzhen Second People’s Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen 518000, ChinaDepartment of Urology, Shenzhen Second People’s Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen 518000, ChinaRevealing the gene regulation networks governing cancer initiation and development is necessary while it remains uncompleted. In recent years, enhancers have been reported to be widely transcribed, resulting in the generation of enhancer RNAs (eRNAs). Previous studies have reported that eRNAs are a subclass of long noncoding RNAs (lncRNAs), which play a critical role in gene regulation and cancer development. These eRNAs can promote enhancer-promoter (E-P) looping formation by binding to other protein factors or propel expression of downstream protein-coding gene. In this review, we have focused on the characteristics of eRNAs and illustrated the biological function and potential mechanism of eRNAs in regulating gene expression and cancer development.http://dx.doi.org/10.1155/2018/2405351
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Yuhan Liu Mengting Ding Qunjun Gao Anbang He Yuchen Liu Hongbing Mei
spellingShingle	Yuhan Liu Mengting Ding Qunjun Gao Anbang He Yuchen Liu Hongbing Mei Current Advances on the Important Roles of Enhancer RNAs in Gene Regulation and Cancer BioMed Research International
author_facet	Yuhan Liu Mengting Ding Qunjun Gao Anbang He Yuchen Liu Hongbing Mei
author_sort	Yuhan Liu
title	Current Advances on the Important Roles of Enhancer RNAs in Gene Regulation and Cancer
title_short	Current Advances on the Important Roles of Enhancer RNAs in Gene Regulation and Cancer
title_full	Current Advances on the Important Roles of Enhancer RNAs in Gene Regulation and Cancer
title_fullStr	Current Advances on the Important Roles of Enhancer RNAs in Gene Regulation and Cancer
title_full_unstemmed	Current Advances on the Important Roles of Enhancer RNAs in Gene Regulation and Cancer
title_sort	current advances on the important roles of enhancer rnas in gene regulation and cancer
publisher	Hindawi Limited
series	BioMed Research International
issn	2314-6133 2314-6141
publishDate	2018-01-01
description	Revealing the gene regulation networks governing cancer initiation and development is necessary while it remains uncompleted. In recent years, enhancers have been reported to be widely transcribed, resulting in the generation of enhancer RNAs (eRNAs). Previous studies have reported that eRNAs are a subclass of long noncoding RNAs (lncRNAs), which play a critical role in gene regulation and cancer development. These eRNAs can promote enhancer-promoter (E-P) looping formation by binding to other protein factors or propel expression of downstream protein-coding gene. In this review, we have focused on the characteristics of eRNAs and illustrated the biological function and potential mechanism of eRNAs in regulating gene expression and cancer development.
url	http://dx.doi.org/10.1155/2018/2405351
work_keys_str_mv	AT yuhanliu currentadvancesontheimportantrolesofenhancerrnasingeneregulationandcancer AT mengtingding currentadvancesontheimportantrolesofenhancerrnasingeneregulationandcancer AT qunjungao currentadvancesontheimportantrolesofenhancerrnasingeneregulationandcancer AT anbanghe currentadvancesontheimportantrolesofenhancerrnasingeneregulationandcancer AT yuchenliu currentadvancesontheimportantrolesofenhancerrnasingeneregulationandcancer AT hongbingmei currentadvancesontheimportantrolesofenhancerrnasingeneregulationandcancer
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Current Advances on the Important Roles of Enhancer RNAs in Gene Regulation and Cancer

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