Structures of Two Melanoma-Associated Antigens Suggest Allosteric Regulation of Effector Binding.

The MAGE (melanoma associated antigen) protein family are tumour-associated proteins normally present only in reproductive tissues such as germ cells of the testis. The human genome encodes over 60 MAGE genes of which one class (containing MAGE-A3 and MAGE-A4) are exclusively expressed in tumours, m...

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Bibliographic Details
Main Authors: Joseph A Newman, Christopher D O Cooper, Anette K Roos, Hazel Aitkenhead, Udo C T Oppermann, Hearn J Cho, Roman Osman, Opher Gileadi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4766014?pdf=render