Building bridges toward invasion: tumor promoter treatment induces a novel protein kinase C-dependent phenotype in MCF10A mammary cell acini.

Building bridges toward invasion: tumor promoter treatment induces a novel protein kinase C-dependent phenotype in MCF10A mammary cell acini.

The potent tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) alters many cellular processes through activation of its receptor protein kinase C (PKC), including gene expression, cell cycle, and the regulation of cell morphology, raising an important question for developing targeted methods t...

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Bibliographic Details
Main Authors: Kristine S Klos, Janel K Warmka, Disa M Drachenberg, Liang Chang, G W Gant Luxton, Cheuk T Leung, Kathryn L Schwertfeger, Elizabeth V Wattenberg
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3944432?pdf=render

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http://europepmc.org/articles/PMC3944432?pdf=render

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