| Summary: | Hepatitis B virus (HBV), hepatitis C virus (HCV) and hepatitis D virus (HDV) are the leading cause of chronic liver diseases. The aims of the present study are to determine the etiological relationship of HBV and HCV in patients with chronic liver disease in North-Eastern Bulgaria and prevalence of dual and triple infections. A total of 434 patients were investigated for HBsAg, 402 of whom were also tested for anti-HCV. The HBsAg positive subjects were tested for anti-HDV and 32 of them also for HbeAg/anti-Hbe. Separated commercial ELISA kits were used. HBsAg was detected in 132 (30.4%); 10.6% were co-infected with HDV. Anti-HCV was detected in 15.4%. Five of 132 HbsAg positive patients (3.78%) were simultaneously HBV and HCV positive. Two patients out of 132 (1.52%) were positive to HBV, HCV and HDV. Our data indicate that HBV infection was the main cause of chronic liver diseases in North-Eastern Bulgaria, and 10.6% of the patients suffered from severe disease because of co-infection with HDV. HCV plays the same role in 15.4% of the cases. Recently, we observed dually infected (HBV and HCV) and triple infected (HBV, HCV, HDV) patients suffering from severe chronic liver diseases.
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