Mangiferin Reduces the Inhibition of Chondrogenic Differentiation by IL-1β in Mesenchymal Stem Cells from Subchondral Bone and Targets Multiple Aspects of the Smad and SOX9 Pathways

Mangiferin Reduces the Inhibition of Chondrogenic Differentiation by IL-1β in Mesenchymal Stem Cells from Subchondral Bone and Targets Multiple Aspects of the Smad and SOX9 Pathways

Mangiferin is a natural immunomodulator found in plants including mango trees. The effects of mangiferin on chondrogenesis and cartilage repair have not yet been reported. This study was designed to determine the effect of mangiferin on chondrogenic differentiation in IL-1β-stimulated mesenchymal st...

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Bibliographic Details
Main Authors: Jeong-Eun Huh, Pil-Seong Koh, Byung-Kwan Seo, Yeon-Chul Park, Yong-Hyun Baek, Jae-Dong Lee, Dong-Suk Park
Format: Article
Language:English
Published: MDPI AG 2014-09-01
Series:International Journal of Molecular Sciences
Subjects:
mangiferin
chondrogenic differentiation
mesenchymal stem cells
Smads
sex-determining region Y–box (SRY-box) containing gene 9 (SOX9)
Online Access:http://www.mdpi.com/1422-0067/15/9/16025

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