Hematopoietic Cell Kinase (HCK) Is Essential for NLRP3 Inflammasome Activation and Lipopolysaccharide-Induced Inflammatory Response In Vivo

Hematopoietic Cell Kinase (HCK) Is Essential for NLRP3 Inflammasome Activation and Lipopolysaccharide-Induced Inflammatory Response In Vivo

Activation of the NLRP3 inflammasome results in caspase 1 cleavage, which subsequently leads to IL-1β and IL-18 secretion, as well as pyroptosis, and aberrant activation of the inflammasome is involved in several diseases such as type 2 diabetes, atherosclerosis, multiple sclerosis, Parkinson’s dise...

Full description

Bibliographic Details
Main Authors: Xiangxi Kong, Yajin Liao, Lujun Zhou, Ying Zhang, Jinbo Cheng, Zengqiang Yuan, Shukun Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Pharmacology
Subjects:
nod-like receptor family protein 3
inflammasome
hematopoietic cell kinase
macrophage
microglia
A419259
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.581011/full

Similar Items

Similar Items