Interleukin-33 regulates metabolic reprogramming of the retinal pigment epithelium in response to immune stressors

Interleukin-33 regulates metabolic reprogramming of the retinal pigment epithelium in response to immune stressors

It remains unresolved how retinal pigment epithelial cell metabolism is regulated following immune activation to maintain retinal homeostasis and retinal function. We exposed retinal pigment epithelium (RPE) to several stress signals, particularly Toll-like receptor stimulation, and uncovered an abi...

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Bibliographic Details
Main Authors: Louis M. Scott, Emma E. Vincent, Natalie Hudson, Chris Neal, Nicholas Jones, Ed C. Lavelle, Matthew Campbell, Andrew P. Halestrap, Andrew D. Dick, Sofia Theodoropoulou
Format: Article
Language:English
Published: American Society for Clinical investigation 2021-04-01
Series:JCI Insight
Subjects:
Metabolism
Ophthalmology
Online Access:https://doi.org/10.1172/jci.insight.129429

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