Absence of the calcium-binding protein calretinin, not of calbindin D-28k, causes a permanent impairment of murine adult hippocampal neurogenesis

Absence of the calcium-binding protein calretinin, not of calbindin D-28k, causes a permanent impairment of murine adult hippocampal neurogenesis

Calretinin (CR) and calbindin D-28k (CB) are cytosolic EF-hand Ca2+-binding proteins and function as Ca2+ buffers affecting the spatiotemporal aspects of Ca2+ transients and possibly also as Ca2+ sensors modulating signaling cascades. In the adult hippocampal circuitry, CR and CB are expressed in sp...

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Bibliographic Details
Main Authors: Kiran eTodkar, Alessandra eScotti, Beat eSchwaller
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-04-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Dentate Gyrus
adult neurogenesis
calbindin
calretinin
calcium buffer
calcium sensor
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnmol.2012.00056/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnmol.2012.00056/full

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