Delineating the role of FANCA in glucose-stimulated insulin secretion in β cells through its protein interactome.

Delineating the role of FANCA in glucose-stimulated insulin secretion in β cells through its protein interactome.

Hyperinsulinemia affects 72% of Fanconi anemia (FA) patients and an additional 25% experience lowered glucose tolerance or frank diabetes. The underlying molecular mechanisms contributing to the dysfunction of FA pancreas β cells is unknown. Therefore, we sought to evaluate the functional role of FA...

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Main Authors: Dragana Lagundžin, Wen-Feng Hu, Henry C H Law, Kimiko L Krieger, Fangfang Qiao, Emalie J Clement, Andjela T Drincic, Olgica Nedić, Michael J Naldrett, Sophie Alvarez, Nicholas T Woods
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0220568

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