Activation of р-450-depended monooxygenases changing immunotoxicity of phosphoroorganic compounds due to their metabolism character
It was established that the application of the monooxygenase system inductors (MSI) of phenobarbital and benzonal up to acute poisoning of animals by trichlorfom in a dose of 1,0 LD50, metabolized in the organism till production of compounds with higher toxicity caused its immunotoxic properties inc...
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Saratov State Medical University
2010-03-01
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| Series: | Саратовский научно-медицинский журнал |
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| Online Access: | http://www.ssmj.ru/system/files/201001_046_048.pdf |
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doaj-43c9eb2838d942faa75ef077c4ba32182021-07-02T03:09:45ZrusSaratov State Medical UniversityСаратовский научно-медицинский журнал1995-00392076-25182010-03-0161046048Activation of р-450-depended monooxygenases changing immunotoxicity of phosphoroorganic compounds due to their metabolism characterP.F. ZabrodskyV.F. KirichukV.G. LimI.Kh. YafarovaIt was established that the application of the monooxygenase system inductors (MSI) of phenobarbital and benzonal up to acute poisoning of animals by trichlorfom in a dose of 1,0 LD50, metabolized in the organism till production of compounds with higher toxicity caused its immunotoxic properties increase. The experiment was carried out on outbred white rats. the acute dimethyldichlorvinylphosphate (1,0 LD50) poisoning, biotransformation of which proceeded with formation of less-toxic and non-toxic compounds after MSI introduction, caused its decrease of suppression influence on immunity system indices http://www.ssmj.ru/system/files/201001_046_048.pdfbenzonalchlorophoscytochrome Р-450dimethyldichlorovinylphosphateimmunotoxycityphenobarbital |
| collection |
DOAJ |
| language |
Russian |
| format |
Article |
| sources |
DOAJ |
| author |
P.F. Zabrodsky V.F. Kirichuk V.G. Lim I.Kh. Yafarova |
| spellingShingle |
P.F. Zabrodsky V.F. Kirichuk V.G. Lim I.Kh. Yafarova Activation of р-450-depended monooxygenases changing immunotoxicity of phosphoroorganic compounds due to their metabolism character Саратовский научно-медицинский журнал benzonal chlorophos cytochrome Р-450 dimethyldichlorovinylphosphate immunotoxycity phenobarbital |
| author_facet |
P.F. Zabrodsky V.F. Kirichuk V.G. Lim I.Kh. Yafarova |
| author_sort |
P.F. Zabrodsky |
| title |
Activation of р-450-depended monooxygenases changing immunotoxicity of phosphoroorganic compounds due to their metabolism character |
| title_short |
Activation of р-450-depended monooxygenases changing immunotoxicity of phosphoroorganic compounds due to their metabolism character |
| title_full |
Activation of р-450-depended monooxygenases changing immunotoxicity of phosphoroorganic compounds due to their metabolism character |
| title_fullStr |
Activation of р-450-depended monooxygenases changing immunotoxicity of phosphoroorganic compounds due to their metabolism character |
| title_full_unstemmed |
Activation of р-450-depended monooxygenases changing immunotoxicity of phosphoroorganic compounds due to their metabolism character |
| title_sort |
activation of р-450-depended monooxygenases changing immunotoxicity of phosphoroorganic compounds due to their metabolism character |
| publisher |
Saratov State Medical University |
| series |
Саратовский научно-медицинский журнал |
| issn |
1995-0039 2076-2518 |
| publishDate |
2010-03-01 |
| description |
It was established that the application of the monooxygenase system inductors (MSI) of phenobarbital and benzonal up to acute poisoning of animals by trichlorfom in a dose of 1,0 LD50, metabolized in the organism till production of compounds with higher toxicity caused its immunotoxic properties increase. The experiment was carried out on outbred white rats. the acute dimethyldichlorvinylphosphate (1,0 LD50) poisoning, biotransformation of which proceeded with formation of less-toxic and non-toxic compounds after MSI introduction, caused its decrease of suppression influence on immunity system indices |
| topic |
benzonal chlorophos cytochrome Р-450 dimethyldichlorovinylphosphate immunotoxycity phenobarbital |
| url |
http://www.ssmj.ru/system/files/201001_046_048.pdf |
| work_keys_str_mv |
AT pfzabrodsky activationofr450dependedmonooxygenaseschangingimmunotoxicityofphosphoroorganiccompoundsduetotheirmetabolismcharacter AT vfkirichuk activationofr450dependedmonooxygenaseschangingimmunotoxicityofphosphoroorganiccompoundsduetotheirmetabolismcharacter AT vglim activationofr450dependedmonooxygenaseschangingimmunotoxicityofphosphoroorganiccompoundsduetotheirmetabolismcharacter AT ikhyafarova activationofr450dependedmonooxygenaseschangingimmunotoxicityofphosphoroorganiccompoundsduetotheirmetabolismcharacter |
| _version_ |
1721342054418612224 |