The Occurrence and Biological Activity of Tormentic Acid—A Review

This review focuses on the natural sources and pharmacological activity of tormentic acid (TA; 2α,3β,19α-trihydroxyurs-2-en-28-oic acid). The current knowledge of its occurrence in various plant species and families is summarized. Biological activity (e.g., anti-inflammatory, antidiabetic, antihyper...

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Main Authors:	Marta Olech, Wojciech Ziemichód, Natalia Nowacka-Jechalke
Format:	Article
Language:	English
Published:	MDPI AG 2021-06-01
Series:	Molecules
Subjects:	tormentic acid triterpenes pentacyclic triterpene CAS 13850-16-3 bioactivity plant metabolite
Online Access:	https://www.mdpi.com/1420-3049/26/13/3797

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spelling	doaj-43c9c12d60d846ff81a487e2b52f4a7a2021-07-15T15:41:56ZengMDPI AGMolecules1420-30492021-06-01263797379710.3390/molecules26133797The Occurrence and Biological Activity of Tormentic Acid—A ReviewMarta Olech0Wojciech Ziemichód1Natalia Nowacka-Jechalke2Chair and Department of Pharmaceutical Botany, Medical University of Lublin, 1 Chodźki Street, 20-093 Lublin, PolandChair and Department of Pharmaceutical Botany, Medical University of Lublin, 1 Chodźki Street, 20-093 Lublin, PolandChair and Department of Pharmaceutical Botany, Medical University of Lublin, 1 Chodźki Street, 20-093 Lublin, PolandThis review focuses on the natural sources and pharmacological activity of tormentic acid (TA; 2α,3β,19α-trihydroxyurs-2-en-28-oic acid). The current knowledge of its occurrence in various plant species and families is summarized. Biological activity (e.g., anti-inflammatory, antidiabetic, antihyperlipidemic, hepatoprotective, cardioprotective, neuroprotective, anti-cancer, anti-osteoarthritic, antinociceptive, antioxidative, anti-melanogenic, cytotoxic, antimicrobial, and antiparasitic) confirmed in in vitro and in vivo studies is compiled and described. Biochemical mechanisms affected by TA are indicated. Moreover, issues related to the biotechnological methods of production, effective eluents, and TA derivatives are presented.https://www.mdpi.com/1420-3049/26/13/3797tormentic acidtriterpenespentacyclic triterpeneCAS 13850-16-3bioactivityplant metabolite
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Marta Olech Wojciech Ziemichód Natalia Nowacka-Jechalke
spellingShingle	Marta Olech Wojciech Ziemichód Natalia Nowacka-Jechalke The Occurrence and Biological Activity of Tormentic Acid—A Review Molecules tormentic acid triterpenes pentacyclic triterpene CAS 13850-16-3 bioactivity plant metabolite
author_facet	Marta Olech Wojciech Ziemichód Natalia Nowacka-Jechalke
author_sort	Marta Olech
title	The Occurrence and Biological Activity of Tormentic Acid—A Review
title_short	The Occurrence and Biological Activity of Tormentic Acid—A Review
title_full	The Occurrence and Biological Activity of Tormentic Acid—A Review
title_fullStr	The Occurrence and Biological Activity of Tormentic Acid—A Review
title_full_unstemmed	The Occurrence and Biological Activity of Tormentic Acid—A Review
title_sort	occurrence and biological activity of tormentic acid—a review
publisher	MDPI AG
series	Molecules
issn	1420-3049
publishDate	2021-06-01
description	This review focuses on the natural sources and pharmacological activity of tormentic acid (TA; 2α,3β,19α-trihydroxyurs-2-en-28-oic acid). The current knowledge of its occurrence in various plant species and families is summarized. Biological activity (e.g., anti-inflammatory, antidiabetic, antihyperlipidemic, hepatoprotective, cardioprotective, neuroprotective, anti-cancer, anti-osteoarthritic, antinociceptive, antioxidative, anti-melanogenic, cytotoxic, antimicrobial, and antiparasitic) confirmed in in vitro and in vivo studies is compiled and described. Biochemical mechanisms affected by TA are indicated. Moreover, issues related to the biotechnological methods of production, effective eluents, and TA derivatives are presented.
topic	tormentic acid triterpenes pentacyclic triterpene CAS 13850-16-3 bioactivity plant metabolite
url	https://www.mdpi.com/1420-3049/26/13/3797
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The Occurrence and Biological Activity of Tormentic Acid—A Review

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