Neonatal therapy with clenbuterol and salmeterol restores spinogenesis and dendritic complexity in the dentate gyrus of the Ts65Dn model of Down syndrome

Neonatal therapy with clenbuterol and salmeterol restores spinogenesis and dendritic complexity in the dentate gyrus of the Ts65Dn model of Down syndrome

Down syndrome (DS), a neurodevelopmental disorder caused by triplication of chromosome 21, is characterized by intellectual disability. In DS, defective neurogenesis causes an overall reduction in the number of neurons populating the brain and defective neuron maturation causes dendritic hypotrophy...

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Bibliographic Details
Main Authors: Marco Emili, Fiorenza Stagni, Maria Elisa Salvalai, Beatrice Uguagliati, Andrea Giacomini, Christelle Albac, Marie-Claude Potier, Mariagrazia Grilli, Renata Bartesaghi, Sandra Guidi
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Neurobiology of Disease
Subjects:
Down syndrome
Ts65Dn model
Dendritic pathology
Spine density
Dendritic complexity
Pharmacotherapy
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996120301492

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