Defective internal allosteric network imparts dysfunctional ATP/substrate-binding cooperativity in oncogenic chimera of protein kinase A
Olivieri, Walker, Karamafrooz et al. show that the fusion of the dynamic J-domain to PKA-C (PKA-CDNAJB1) disrupts the internal allosteric network, attenuating the nucleotide/PKI binding cooperativity. This study suggests that the reduced allosteric cooperativity may contribute to the pathology that...
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Bibliographic Details
| Main Authors: |
Cristina Olivieri,
Caitlin Walker,
Adak Karamafrooz,
Yingjie Wang,
V. S. Manu,
Fernando Porcelli,
Donald K. Blumenthal,
David D. Thomas,
David A. Bernlohr,
Simon M. Sandford,
Susan S. Taylor,
Gianluigi Veglia |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2021-03-01
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| Series: | Communications Biology
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| Online Access: | https://doi.org/10.1038/s42003-021-01819-6
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