Evolutionary Origins of DNA Repair Pathways: Role of Oxygen Catastrophe in the Emergence of DNA Glycosylases

Evolutionary Origins of DNA Repair Pathways: Role of Oxygen Catastrophe in the Emergence of DNA Glycosylases

It was proposed that the last universal common ancestor (LUCA) evolved under high temperatures in an oxygen-free environment, similar to those found in deep-sea vents and on volcanic slopes. Therefore, spontaneous DNA decay, such as base loss and cytosine deamination, was the major factor affecting...

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Bibliographic Details
Main Authors: Paulina Prorok, Inga R. Grin, Bakhyt T. Matkarimov, Alexander A. Ishchenko, Jacques Laval, Dmitry O. Zharkov, Murat Saparbaev
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Cells
Subjects:
DNA repair
DNA glycosylases
AP endonucleases
protein folds
structural homology
Online Access:https://www.mdpi.com/2073-4409/10/7/1591

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