A Rare Manifestation of a Rare Disease: Mantle Cell Lymphoma Presenting With Aseptic Meningitis

Mantle cell lymphoma (MCL) is a rare form of non-Hodgkin lymphoma characterized by clonal proliferation of follicular mantle zone B lymphocytes. It is caused by abnormal chromosomal translocation t(11;14) resulting in aberrant expression of cyclin D1. This leads to activation of anti-apoptotic pathw...

Full description

Bibliographic Details
Main Authors:	Elvira Umyarova MD, Sreedhar Adapa MD, Srikanth Naramala MD, Vijay Gayam MD, Narothama Reddy Aeddula MD, Venu Madhav Konala MD
Format:	Article
Language:	English
Published:	SAGE Publishing 2019-06-01
Series:	Journal of Investigative Medicine High Impact Case Reports
Online Access:	https://doi.org/10.1177/2324709619858643

id	doaj-43bbe482ed80450c8a3dc8cb64ebb32b
record_format	Article
spelling	doaj-43bbe482ed80450c8a3dc8cb64ebb32b2020-11-25T02:47:51ZengSAGE PublishingJournal of Investigative Medicine High Impact Case Reports2324-70962019-06-01710.1177/2324709619858643A Rare Manifestation of a Rare Disease: Mantle Cell Lymphoma Presenting With Aseptic MeningitisElvira Umyarova MD0Sreedhar Adapa MD1Srikanth Naramala MD2Vijay Gayam MD3Narothama Reddy Aeddula MD4Venu Madhav Konala MD5University of Vermont, Burlington, VT, USAKaweah Delta Medical Center, Visalia, CA, USAAdventist Medical Center Hanford, Hanford, CA, USAInterfaith Medical Center, Brooklyn, NY, USADeaconess Health System Inc, Evansville, IN, USAAshland-Bellefonte Cancer Center, Ashland, KY, USAMantle cell lymphoma (MCL) is a rare form of non-Hodgkin lymphoma characterized by clonal proliferation of follicular mantle zone B lymphocytes. It is caused by abnormal chromosomal translocation t(11;14) resulting in aberrant expression of cyclin D1. This leads to activation of anti-apoptotic pathways and abnormal proliferation of MCL cells. Patients can present with an indolent course or a fulminant disease with short overall survival. The disease frequently involves extranodal organs, but rarely manifests with neurological symptoms. We report a rare case of aberrant CD5-negative MCL presenting with aseptic meningitis.https://doi.org/10.1177/2324709619858643
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Elvira Umyarova MD Sreedhar Adapa MD Srikanth Naramala MD Vijay Gayam MD Narothama Reddy Aeddula MD Venu Madhav Konala MD
spellingShingle	Elvira Umyarova MD Sreedhar Adapa MD Srikanth Naramala MD Vijay Gayam MD Narothama Reddy Aeddula MD Venu Madhav Konala MD A Rare Manifestation of a Rare Disease: Mantle Cell Lymphoma Presenting With Aseptic Meningitis Journal of Investigative Medicine High Impact Case Reports
author_facet	Elvira Umyarova MD Sreedhar Adapa MD Srikanth Naramala MD Vijay Gayam MD Narothama Reddy Aeddula MD Venu Madhav Konala MD
author_sort	Elvira Umyarova MD
title	A Rare Manifestation of a Rare Disease: Mantle Cell Lymphoma Presenting With Aseptic Meningitis
title_short	A Rare Manifestation of a Rare Disease: Mantle Cell Lymphoma Presenting With Aseptic Meningitis
title_full	A Rare Manifestation of a Rare Disease: Mantle Cell Lymphoma Presenting With Aseptic Meningitis
title_fullStr	A Rare Manifestation of a Rare Disease: Mantle Cell Lymphoma Presenting With Aseptic Meningitis
title_full_unstemmed	A Rare Manifestation of a Rare Disease: Mantle Cell Lymphoma Presenting With Aseptic Meningitis
title_sort	rare manifestation of a rare disease: mantle cell lymphoma presenting with aseptic meningitis
publisher	SAGE Publishing
series	Journal of Investigative Medicine High Impact Case Reports
issn	2324-7096
publishDate	2019-06-01
description	Mantle cell lymphoma (MCL) is a rare form of non-Hodgkin lymphoma characterized by clonal proliferation of follicular mantle zone B lymphocytes. It is caused by abnormal chromosomal translocation t(11;14) resulting in aberrant expression of cyclin D1. This leads to activation of anti-apoptotic pathways and abnormal proliferation of MCL cells. Patients can present with an indolent course or a fulminant disease with short overall survival. The disease frequently involves extranodal organs, but rarely manifests with neurological symptoms. We report a rare case of aberrant CD5-negative MCL presenting with aseptic meningitis.
url	https://doi.org/10.1177/2324709619858643
work_keys_str_mv	AT elviraumyarovamd araremanifestationofararediseasemantlecelllymphomapresentingwithasepticmeningitis AT sreedharadapamd araremanifestationofararediseasemantlecelllymphomapresentingwithasepticmeningitis AT srikanthnaramalamd araremanifestationofararediseasemantlecelllymphomapresentingwithasepticmeningitis AT vijaygayammd araremanifestationofararediseasemantlecelllymphomapresentingwithasepticmeningitis AT narothamareddyaeddulamd araremanifestationofararediseasemantlecelllymphomapresentingwithasepticmeningitis AT venumadhavkonalamd araremanifestationofararediseasemantlecelllymphomapresentingwithasepticmeningitis AT elviraumyarovamd raremanifestationofararediseasemantlecelllymphomapresentingwithasepticmeningitis AT sreedharadapamd raremanifestationofararediseasemantlecelllymphomapresentingwithasepticmeningitis AT srikanthnaramalamd raremanifestationofararediseasemantlecelllymphomapresentingwithasepticmeningitis AT vijaygayammd raremanifestationofararediseasemantlecelllymphomapresentingwithasepticmeningitis AT narothamareddyaeddulamd raremanifestationofararediseasemantlecelllymphomapresentingwithasepticmeningitis AT venumadhavkonalamd raremanifestationofararediseasemantlecelllymphomapresentingwithasepticmeningitis
_version_	1724750876150595584

A Rare Manifestation of a Rare Disease: Mantle Cell Lymphoma Presenting With Aseptic Meningitis

Similar Items