Role of Substance P and Its Receptor Neurokinin 1 in Chronic Prurigo: A Randomized, Proof-of-Concept, Controlled Trial with Topical Aprepitant

Role of Substance P and Its Receptor Neurokinin 1 in Chronic Prurigo: A Randomized, Proof-of-Concept, Controlled Trial with Topical Aprepitant

Substance P (SP) and its receptor neurokinin 1 (NK1R) are thought to be involved in the pathogenesis of chronic prurigo. Here, we assessed SP serum levels, cutaneous NK1R expression, and the effects of topical aprepitant, an NK1R antagonist, in patients with chronic prurigo. SP and NK1R were increas...

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Bibliographic Details
Main Authors: Tatevik Ohanyan, Nicole Schoepke, Stefan Eirefelt, Gert Hoey, Witte Koopmann, Tomasz Hawro, Marcus Maurer, Martin Metz
Format: Article
Language:English
Published: Society for Publication of Acta Dermato-Venereologica 2017-09-01
Series:Acta Dermato-Venereologica
Subjects:
prurigo
aprepitant
substanceP
NK1R
lesionalskin
pruritusintensity
Online Access: https://www.medicaljournals.se/acta/content/html/10.2340/00015555-2780

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