Potential Benefits of Tryptophan Metabolism to the Efficacy of Tocilizumab in COVID-19

Potential Benefits of Tryptophan Metabolism to the Efficacy of Tocilizumab in COVID-19

Tocilizumab has been proposed as a means of opposing hyperinflammatory responses in intensive care patients with COVID-19. Here, we briefly discuss the potentially multiple, synergistic mechanisms whereby tocilizumab might exert therapeutic activity, mostly focusing on the production of tryptophan-d...

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Bibliographic Details
Main Authors: Maria Laura Belladonna, Ciriana Orabona
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Pharmacology
Subjects:
COVID-19
tocilizumab
tryptophan catabolism
IDO1
cytokine storm syndrome
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00959/full
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spelling doaj-43b65e36abb74be7b706e5ed402a72962020-11-25T02:53:53ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122020-06-011110.3389/fphar.2020.00959556097Potential Benefits of Tryptophan Metabolism to the Efficacy of Tocilizumab in COVID-19Maria Laura BelladonnaCiriana OrabonaTocilizumab has been proposed as a means of opposing hyperinflammatory responses in intensive care patients with COVID-19. Here, we briefly discuss the potentially multiple, synergistic mechanisms whereby tocilizumab might exert therapeutic activity, mostly focusing on the production of tryptophan-derived catabolites that would result from blockade of IL-6 signaling, as contextualized to the cytokine storm occurring in COVID-19 patients.https://www.frontiersin.org/article/10.3389/fphar.2020.00959/fullCOVID-19tocilizumabtryptophan catabolismIDO1cytokine storm syndrome
collection DOAJ
language English
format Article
sources DOAJ
author Maria Laura Belladonna
Ciriana Orabona
spellingShingle Maria Laura Belladonna
Ciriana Orabona
Potential Benefits of Tryptophan Metabolism to the Efficacy of Tocilizumab in COVID-19
Frontiers in Pharmacology
COVID-19
tocilizumab
tryptophan catabolism
IDO1
cytokine storm syndrome
author_facet Maria Laura Belladonna
Ciriana Orabona
author_sort Maria Laura Belladonna
title Potential Benefits of Tryptophan Metabolism to the Efficacy of Tocilizumab in COVID-19
title_short Potential Benefits of Tryptophan Metabolism to the Efficacy of Tocilizumab in COVID-19
title_full Potential Benefits of Tryptophan Metabolism to the Efficacy of Tocilizumab in COVID-19
title_fullStr Potential Benefits of Tryptophan Metabolism to the Efficacy of Tocilizumab in COVID-19
title_full_unstemmed Potential Benefits of Tryptophan Metabolism to the Efficacy of Tocilizumab in COVID-19
title_sort potential benefits of tryptophan metabolism to the efficacy of tocilizumab in covid-19
publisher Frontiers Media S.A.
series Frontiers in Pharmacology
issn 1663-9812
publishDate 2020-06-01
description Tocilizumab has been proposed as a means of opposing hyperinflammatory responses in intensive care patients with COVID-19. Here, we briefly discuss the potentially multiple, synergistic mechanisms whereby tocilizumab might exert therapeutic activity, mostly focusing on the production of tryptophan-derived catabolites that would result from blockade of IL-6 signaling, as contextualized to the cytokine storm occurring in COVID-19 patients.
topic COVID-19
tocilizumab
tryptophan catabolism
IDO1
cytokine storm syndrome
url https://www.frontiersin.org/article/10.3389/fphar.2020.00959/full
work_keys_str_mv AT marialaurabelladonna potentialbenefitsoftryptophanmetabolismtotheefficacyoftocilizumabincovid19
AT cirianaorabona potentialbenefitsoftryptophanmetabolismtotheefficacyoftocilizumabincovid19
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