Comparative Plasma Exposure of Albendazole after Administration of Rapidly Disintegrating Tablets in Dogs

The main objectives of this study were (a) to evaluate the in vitro performance of the rapid disintegration tablets as a way to improve the solid dispersions and (b) to study the in vivo pharmacokinetics of the albendazole modified formulation in dogs. Rapid disintegration of tablets seems to be a k...

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Main Authors:	Silvina G. Castro, Alicia Dib, Gonzalo Suarez, Daniel Allemandi, Carlos Lanusse, Sergio Sanchez Bruni, Santiago D. Palma
Format:	Article
Language:	English
Published:	Hindawi Limited 2013-01-01
Series:	BioMed Research International
Online Access:	http://dx.doi.org/10.1155/2013/920305

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spelling	doaj-43abbb32bdd44b8bb2f788dbd0b5f4712020-11-24T20:54:17ZengHindawi LimitedBioMed Research International2314-61332314-61412013-01-01201310.1155/2013/920305920305Comparative Plasma Exposure of Albendazole after Administration of Rapidly Disintegrating Tablets in DogsSilvina G. Castro0Alicia Dib1Gonzalo Suarez2Daniel Allemandi3Carlos Lanusse4Sergio Sanchez Bruni5Santiago D. Palma6Department of Pharmacy, Faculty of Chemical Sciences, UNITEFA, Universidad Nacional de Córdoba, 5000 Córdoba, ArgentinaLaboratory of Pharmacology, Faculty of Veterinary Medicine, Universidad de la Republica, 11600 Montevideo, UruguayLaboratory of Pharmacology, Faculty of Veterinary Medicine, Universidad de la Republica, 11600 Montevideo, UruguayDepartment of Pharmacy, Faculty of Chemical Sciences, UNITEFA, Universidad Nacional de Córdoba, 5000 Córdoba, ArgentinaConsejo Nacional de Investigaciones Científicas y Técnicas-CONICET, ArgentinaConsejo Nacional de Investigaciones Científicas y Técnicas-CONICET, ArgentinaDepartment of Pharmacy, Faculty of Chemical Sciences, UNITEFA, Universidad Nacional de Córdoba, 5000 Córdoba, ArgentinaThe main objectives of this study were (a) to evaluate the in vitro performance of the rapid disintegration tablets as a way to improve the solid dispersions and (b) to study the in vivo pharmacokinetics of the albendazole modified formulation in dogs. Rapid disintegration of tablets seems to be a key factor for efficiency of solid dispersions with regard to improvement of the albendazole bioavailability. The in vivo assays performed on dogs showed a marked increase in drug plasma exposure when albendazole was given in solid dispersions incorporated into rapid disintegration tablets compared with conventional solid dosage form.http://dx.doi.org/10.1155/2013/920305
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Silvina G. Castro Alicia Dib Gonzalo Suarez Daniel Allemandi Carlos Lanusse Sergio Sanchez Bruni Santiago D. Palma
spellingShingle	Silvina G. Castro Alicia Dib Gonzalo Suarez Daniel Allemandi Carlos Lanusse Sergio Sanchez Bruni Santiago D. Palma Comparative Plasma Exposure of Albendazole after Administration of Rapidly Disintegrating Tablets in Dogs BioMed Research International
author_facet	Silvina G. Castro Alicia Dib Gonzalo Suarez Daniel Allemandi Carlos Lanusse Sergio Sanchez Bruni Santiago D. Palma
author_sort	Silvina G. Castro
title	Comparative Plasma Exposure of Albendazole after Administration of Rapidly Disintegrating Tablets in Dogs
title_short	Comparative Plasma Exposure of Albendazole after Administration of Rapidly Disintegrating Tablets in Dogs
title_full	Comparative Plasma Exposure of Albendazole after Administration of Rapidly Disintegrating Tablets in Dogs
title_fullStr	Comparative Plasma Exposure of Albendazole after Administration of Rapidly Disintegrating Tablets in Dogs
title_full_unstemmed	Comparative Plasma Exposure of Albendazole after Administration of Rapidly Disintegrating Tablets in Dogs
title_sort	comparative plasma exposure of albendazole after administration of rapidly disintegrating tablets in dogs
publisher	Hindawi Limited
series	BioMed Research International
issn	2314-6133 2314-6141
publishDate	2013-01-01
description	The main objectives of this study were (a) to evaluate the in vitro performance of the rapid disintegration tablets as a way to improve the solid dispersions and (b) to study the in vivo pharmacokinetics of the albendazole modified formulation in dogs. Rapid disintegration of tablets seems to be a key factor for efficiency of solid dispersions with regard to improvement of the albendazole bioavailability. The in vivo assays performed on dogs showed a marked increase in drug plasma exposure when albendazole was given in solid dispersions incorporated into rapid disintegration tablets compared with conventional solid dosage form.
url	http://dx.doi.org/10.1155/2013/920305
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Comparative Plasma Exposure of Albendazole after Administration of Rapidly Disintegrating Tablets in Dogs

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