De Novo Design and In Vitro Testing of Antimicrobial Peptides against Gram-Negative Bacteria

De Novo Design and In Vitro Testing of Antimicrobial Peptides against Gram-Negative Bacteria

Antimicrobial peptides (AMPs) have been identified as a potentially new class of antibiotics to combat bacterial resistance to conventional drugs. The design of de novo AMPs with high therapeutic indexes, low cost of synthesis, high resistance to proteases and high bioavailability remains a challeng...

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Bibliographic Details
Main Authors: Boris Vishnepolsky, George Zaalishvili, Margarita Karapetian, Tornike Nasrashvili, Nato Kuljanishvili, Andrei Gabrielian, Alex Rosenthal, Darrell E. Hurt, Michael Tartakovsky, Maya Grigolava, Malak Pirtskhalava
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Pharmaceuticals
Subjects:
antimicrobial peptides
predictive models
drug design
Online Access:https://www.mdpi.com/1424-8247/12/2/82

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