Functional reconstruction of a eukaryotic-like E1/E2/(RING) E3 ubiquitylation cascade from an uncultured archaeon

In eukaryotic cells, the ubiquitylation system regulates several cellular processes central to protein homoeostasis. Here the authors demonstrate the existence of an eukaryotic-like ubiquitylation cascade requiring E1, E2 and E3-like enzymes in the archaeon C. subterraneum, shedding light on the evo...

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Main Authors:	Rory Hennell James, Eva F. Caceres, Alex Escasinas, Haya Alhasan, Julie A. Howard, Michael J. Deery, Thijs J. G. Ettema, Nicholas P. Robinson
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-10-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-017-01162-7

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spelling	doaj-43a479c725a04e099f110faf35387e012021-05-11T07:06:12ZengNature Publishing GroupNature Communications2041-17232017-10-018111510.1038/s41467-017-01162-7Functional reconstruction of a eukaryotic-like E1/E2/(RING) E3 ubiquitylation cascade from an uncultured archaeonRory Hennell James0Eva F. Caceres1Alex Escasinas2Haya Alhasan3Julie A. Howard4Michael J. Deery5Thijs J. G. Ettema6Nicholas P. Robinson7Department of Biochemistry, The University of CambridgeDepartment of Cell and Molecular Biology, Science for Life Laboratory, Uppsala UniversityDivision of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster UniversityDivision of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster UniversityDepartment of Biochemistry and Cambridge Systems Biology Centre, Cambridge Centre for Proteomics, The University of CambridgeDepartment of Biochemistry and Cambridge Systems Biology Centre, Cambridge Centre for Proteomics, The University of CambridgeDepartment of Cell and Molecular Biology, Science for Life Laboratory, Uppsala UniversityDivision of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster UniversityIn eukaryotic cells, the ubiquitylation system regulates several cellular processes central to protein homoeostasis. Here the authors demonstrate the existence of an eukaryotic-like ubiquitylation cascade requiring E1, E2 and E3-like enzymes in the archaeon C. subterraneum, shedding light on the evolution of the ubiquitin-proteasome system.https://doi.org/10.1038/s41467-017-01162-7
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Rory Hennell James Eva F. Caceres Alex Escasinas Haya Alhasan Julie A. Howard Michael J. Deery Thijs J. G. Ettema Nicholas P. Robinson
spellingShingle	Rory Hennell James Eva F. Caceres Alex Escasinas Haya Alhasan Julie A. Howard Michael J. Deery Thijs J. G. Ettema Nicholas P. Robinson Functional reconstruction of a eukaryotic-like E1/E2/(RING) E3 ubiquitylation cascade from an uncultured archaeon Nature Communications
author_facet	Rory Hennell James Eva F. Caceres Alex Escasinas Haya Alhasan Julie A. Howard Michael J. Deery Thijs J. G. Ettema Nicholas P. Robinson
author_sort	Rory Hennell James
title	Functional reconstruction of a eukaryotic-like E1/E2/(RING) E3 ubiquitylation cascade from an uncultured archaeon
title_short	Functional reconstruction of a eukaryotic-like E1/E2/(RING) E3 ubiquitylation cascade from an uncultured archaeon
title_full	Functional reconstruction of a eukaryotic-like E1/E2/(RING) E3 ubiquitylation cascade from an uncultured archaeon
title_fullStr	Functional reconstruction of a eukaryotic-like E1/E2/(RING) E3 ubiquitylation cascade from an uncultured archaeon
title_full_unstemmed	Functional reconstruction of a eukaryotic-like E1/E2/(RING) E3 ubiquitylation cascade from an uncultured archaeon
title_sort	functional reconstruction of a eukaryotic-like e1/e2/(ring) e3 ubiquitylation cascade from an uncultured archaeon
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-10-01
description	In eukaryotic cells, the ubiquitylation system regulates several cellular processes central to protein homoeostasis. Here the authors demonstrate the existence of an eukaryotic-like ubiquitylation cascade requiring E1, E2 and E3-like enzymes in the archaeon C. subterraneum, shedding light on the evolution of the ubiquitin-proteasome system.
url	https://doi.org/10.1038/s41467-017-01162-7
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Functional reconstruction of a eukaryotic-like E1/E2/(RING) E3 ubiquitylation cascade from an uncultured archaeon

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