The Synergistic Use of IL-15 and IL-21 for the Generation of NK Cells From CD3/CD19-Depleted Grafts Improves Their ex vivo Expansion and Cytotoxic Potential Against Neuroblastoma: Perspective for Optimized Immunotherapy Post Haploidentical Stem Cell Transplantation

The Synergistic Use of IL-15 and IL-21 for the Generation of NK Cells From CD3/CD19-Depleted Grafts Improves Their ex vivo Expansion and Cytotoxic Potential Against Neuroblastoma: Perspective for Optimized Immunotherapy Post Haploidentical Stem Cell Transplantation

Neuroblastoma (NB) is the most common solid extracranial tumor in childhood. Despite therapeutic progress, prognosis in high-risk NB is poor and innovative therapies are urgently needed. Therefore, we addressed the potential cytotoxic capacity of interleukin (IL)-activated natural killer (NK) cells...

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Bibliographic Details
Main Authors: Annekathrin Heinze, Beatrice Grebe, Melanie Bremm, Sabine Huenecke, Tasleem Ah. Munir, Lea Graafen, Jochen T. Frueh, Michael Merker, Eva Rettinger, Jan Soerensen, Thomas Klingebiel, Peter Bader, Evelyn Ullrich, Claudia Cappel
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Immunology
Subjects:
immunotherapy
NK cells
CD3/CD19 depletion
CIK cells
IL-21
IL-15
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02816/full

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