Disruption of the ERLIN-TM6SF2-APOB complex destabilizes APOB and contributes to non-alcoholic fatty liver disease.

Disruption of the ERLIN-TM6SF2-APOB complex destabilizes APOB and contributes to non-alcoholic fatty liver disease.

Non-alcoholic fatty liver disease (NAFLD) is a metabolic disorder characterized by excess lipid accumulation in the liver without significant consumption of alcohol. The transmembrane 6 superfamily member 2 (TM6SF2) E167K missense variant strongly associates with NAFLD in humans. The E167K mutation...

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Bibliographic Details
Main Authors:	Bo-Tao Li, Ming Sun, Yun-Feng Li, Ju-Qiong Wang, Zi-Mu Zhou, Bao-Liang Song, Jie Luo
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2020-08-01
Series:	PLoS Genetics
Online Access:	https://doi.org/10.1371/journal.pgen.1008955

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