The Nuclear Receptor LXR Limits Bacterial Infection of Host Macrophages through a Mechanism that Impacts Cellular NAD Metabolism

The Nuclear Receptor LXR Limits Bacterial Infection of Host Macrophages through a Mechanism that Impacts Cellular NAD Metabolism

Macrophages exert potent effector functions against invading microorganisms but constitute, paradoxically, a preferential niche for many bacterial strains to replicate. Using a model of infection by Salmonella Typhimurium, we have identified a molecular mechanism regulated by the nuclear receptor LX...

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Bibliographic Details
Main Authors: Jonathan Matalonga, Estibaliz Glaria, Mariana Bresque, Carlos Escande, José María Carbó, Kerstin Kiefer, Ruben Vicente, Theresa E. León, Susana Beceiro, Mónica Pascual-García, Joan Serret, Lucía Sanjurjo, Samantha Morón-Ros, Antoni Riera, Sonia Paytubi, Antonio Juarez, Fernando Sotillo, Lennart Lindbom, Carme Caelles, Maria-Rosa Sarrias, Jaime Sancho, Antonio Castrillo, Eduardo N. Chini, Annabel F. Valledor
Format: Article
Language:English
Published: Elsevier 2017-01-01
Series:Cell Reports
Subjects:
macrophage
nuclear receptor
LXR
bacterial infection
NAD
cytoskeleton
CD38
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717300256

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http://www.sciencedirect.com/science/article/pii/S2211124717300256

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