Synthesis and Biophysical Insights into the Binding of a Potent Anti-Proliferative Non-symmetric Bis-isatin Derivative with Bovine Serum Albumin: Spectroscopic and Molecular Docking Approaches

Synthesis and Biophysical Insights into the Binding of a Potent Anti-Proliferative Non-symmetric Bis-isatin Derivative with Bovine Serum Albumin: Spectroscopic and Molecular Docking Approaches

As part of the research endeavors to combat cancer, a non-symmetric bis-isatin derivative (compound 3) was synthesized and showed a significant anti-proliferative potency. The current study provides a comprehensive characterization of the interaction of compound 3 with the drug-transporting protein...

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Bibliographic Details
Main Authors: Ali Saber Abdelhameed, Ahmed H. Bakheit, Mostafa S. Mohamed, Wagdy M. Eldehna, Hatem A. Abdel-Aziz, Mohamed I. Attia
Format: Article
Language:English
Published: MDPI AG 2017-06-01
Series:Applied Sciences
Subjects:
fluorescence spectroscopy
bovine serum albumin
isatin derivatives
anti-proliferative agent
Online Access:http://www.mdpi.com/2076-3417/7/6/617

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