The 13-year bleed: Exuberant amyloid angiopathies, angiodysplasias, and acquired coagulopathies of the gut

The 13-year bleed: Exuberant amyloid angiopathies, angiodysplasias, and acquired coagulopathies of the gut

Amyloidosis is a disorder characterized by extracellular deposits of proteins that are prone to aggregate and form insoluble fibrils. Amyloid deposits limited to a single organ or tissue without the involvement of any other site in the body is uncommon. We report a 75-year-old man with previously tr...

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Main Authors: Larnelle N Simms, Laura Suzanne K Suarez, Khaled Deeb, Jose Proenza
Format: Article
Language:English
Published: SAGE Publishing 2021-09-01
Series:SAGE Open Medical Case Reports
Online Access:https://doi.org/10.1177/2050313X211040018
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spelling doaj-4379a24668244d7d923323b5eb70603a2021-09-02T02:33:54ZengSAGE PublishingSAGE Open Medical Case Reports2050-313X2021-09-01910.1177/2050313X211040018The 13-year bleed: Exuberant amyloid angiopathies, angiodysplasias, and acquired coagulopathies of the gutLarnelle N Simms0Laura Suzanne K Suarez1Khaled Deeb2Jose Proenza3Internal Medicine Resident, University of Miami Palm Beach Regional GME Consortium, Atlantis, FL, USAInternal Medicine Resident, University of Miami Palm Beach Regional GME Consortium, Atlantis, FL, USADepartment of Internal Medicine, West Palm Beach Veterans Affairs Medical Center, West Palm Beach, FL, USADepartment of Gastroenterology, West Palm Beach Veterans Affairs Medical Center, West Palm Beach, FL, USAAmyloidosis is a disorder characterized by extracellular deposits of proteins that are prone to aggregate and form insoluble fibrils. Amyloid deposits limited to a single organ or tissue without the involvement of any other site in the body is uncommon. We report a 75-year-old man with previously treated non-Hodgkin’s lymphoma who presented with recurrent gastrointestinal hemorrhage. Histopathology showed amyloid deposition within vascular malformations. His bleeding continued with the cause rooted in the fundamental building blocks—clotting factors. We discuss the interplay of the pathophysiology of lymphoma, amyloidosis, and factor X deficiency in a patient with preexisting angiodysplasias leading to refractory gastrointestinal bleeding. To our knowledge, there are only 3 reported cases of concomitant amyloidosis and angiodysplasia in the colon, and none involving the small bowel.https://doi.org/10.1177/2050313X211040018
collection DOAJ
language English
format Article
sources DOAJ
author Larnelle N Simms
Laura Suzanne K Suarez
Khaled Deeb
Jose Proenza
spellingShingle Larnelle N Simms
Laura Suzanne K Suarez
Khaled Deeb
Jose Proenza
The 13-year bleed: Exuberant amyloid angiopathies, angiodysplasias, and acquired coagulopathies of the gut
SAGE Open Medical Case Reports
author_facet Larnelle N Simms
Laura Suzanne K Suarez
Khaled Deeb
Jose Proenza
author_sort Larnelle N Simms
title The 13-year bleed: Exuberant amyloid angiopathies, angiodysplasias, and acquired coagulopathies of the gut
title_short The 13-year bleed: Exuberant amyloid angiopathies, angiodysplasias, and acquired coagulopathies of the gut
title_full The 13-year bleed: Exuberant amyloid angiopathies, angiodysplasias, and acquired coagulopathies of the gut
title_fullStr The 13-year bleed: Exuberant amyloid angiopathies, angiodysplasias, and acquired coagulopathies of the gut
title_full_unstemmed The 13-year bleed: Exuberant amyloid angiopathies, angiodysplasias, and acquired coagulopathies of the gut
title_sort 13-year bleed: exuberant amyloid angiopathies, angiodysplasias, and acquired coagulopathies of the gut
publisher SAGE Publishing
series SAGE Open Medical Case Reports
issn 2050-313X
publishDate 2021-09-01
description Amyloidosis is a disorder characterized by extracellular deposits of proteins that are prone to aggregate and form insoluble fibrils. Amyloid deposits limited to a single organ or tissue without the involvement of any other site in the body is uncommon. We report a 75-year-old man with previously treated non-Hodgkin’s lymphoma who presented with recurrent gastrointestinal hemorrhage. Histopathology showed amyloid deposition within vascular malformations. His bleeding continued with the cause rooted in the fundamental building blocks—clotting factors. We discuss the interplay of the pathophysiology of lymphoma, amyloidosis, and factor X deficiency in a patient with preexisting angiodysplasias leading to refractory gastrointestinal bleeding. To our knowledge, there are only 3 reported cases of concomitant amyloidosis and angiodysplasia in the colon, and none involving the small bowel.
url https://doi.org/10.1177/2050313X211040018
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