SP-A2 contributes to miRNA-mediated sex differences in response to oxidative stress: pro-inflammatory, anti-apoptotic, and anti-oxidant pathways are involved

SP-A2 contributes to miRNA-mediated sex differences in response to oxidative stress: pro-inflammatory, anti-apoptotic, and anti-oxidant pathways are involved

Abstract Background Human innate host defense molecules, surfactant protein A1 (SP-A1), and SP-A2 differentially affect the function and proteome of the alveolar macrophage (AM). We hypothesized that SP-A genes differentially regulate the AM miRNome. Methods Humanized transgenic mice expressing SP-A...

Full description

Bibliographic Details
Main Authors: George T. Noutsios, Nithyananda Thorenoor, Xuesheng Zhang, David S. Phelps, Todd M. Umstead, Faryal Durrani, Joanna Floros
Format: Article
Language:English
Published: BMC 2017-12-01
Series:Biology of Sex Differences
Subjects:
Surfactant protein A
Ozone
Sex differences
STAT3
IL-6
Online Access:http://link.springer.com/article/10.1186/s13293-017-0158-2

Internet

http://link.springer.com/article/10.1186/s13293-017-0158-2

Similar Items