Specificity of the T Cell Response to Protein Biopharmaceuticals

Specificity of the T Cell Response to Protein Biopharmaceuticals

The anti-drug antibody (ADA) response is an undesired humoral response raised against protein biopharmaceuticals (BPs) which can dramatically disturb their therapeutic properties. One particularity of the ADA response resides in the nature of the immunogens, which are usually human(ized) proteins an...

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Bibliographic Details
Main Authors: Sylvain Meunier, Marie de Bourayne, Moustafa Hamze, Aurélien Azam, Evelyne Correia, Catherine Menier, Bernard Maillère
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Immunology
Subjects:
T cell
biopharmaceuticals
therapeutic antibody
therapeutic protein
immunogenicity
epitope
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01550/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01550/full

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