A conserved hydrophobic patch on Vβ domains revealed by TCRβ chain crystal structures: implications for pre-TCR dimerization

A conserved hydrophobic patch on Vβ domains revealed by TCRβ chain crystal structures: implications for pre-TCR dimerization

The αβ T cell receptor (TCR) is a multimeric complex whose β chain plays a crucial role in thymocyte development as well as antigen recognition by mature T lymphocytes. We report here crystal structures of individual β subunits, termed N15β (Vβ5.2Dβ2Jβ2.6Cβ2) and N30β (Vβ13Dβ1Jβ1.1Cβ2), derived from...

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Bibliographic Details
Main Authors: Bo eZhou, Qiang eChen, Robert eMallis, Hongmin eZhang, Jin-huan eLiu, Ellis L Reinherz, Jia-huai eWang
Format: Article
Language:English
Published: Frontiers Media S.A. 2011-03-01
Series:Frontiers in Immunology
Subjects:
crystal structure
T cell receptor
pre-TCR
beta chain
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2011.00005/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2011.00005/full

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