A two-step mechanism for cell fate decision by coordination of nuclear and mitochondrial p53 activities.

A two-step mechanism for cell fate decision by coordination of nuclear and mitochondrial p53 activities.

The tumor suppressor p53 has a crucial role in the DNA damage response. Here, we proposed an integrated model of the p53 network and explored how the nuclear and mitochondrial p53 pathways are coordinated to determine cell fates after [Formula: see text]-irradiation in radiosensitive tissues. Using...

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Bibliographic Details
Main Authors: Xiao-Jun Tian, Feng Liu, Xiao-Peng Zhang, Jun Li, Wei Wang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3367989?pdf=render

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