Marine-Derived Metabolites of S-Adenosylmethionine as Templates for New Anti-Infectives
S-Adenosylmethionine (AdoMet) is a key biochemical co-factor whose proximate metabolites include methylated macromolecules (e.g., nucleic acids, proteins, phospholipids), methylated small molecules (e.g., sterols, biogenic amines), polyamines (e.g., spermidine, spermine), ethylene, and N-acyl-homose...
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| Format: | Article |
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MDPI AG
2009-08-01
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| Series: | Marine Drugs |
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| Online Access: | http://www.mdpi.com/1660-3397/7/3/401/ |
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Article |
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doaj-43528f0208c744e5942e65d6d9c6b1532020-11-24T22:18:17ZengMDPI AGMarine Drugs1660-33972009-08-017340143410.3390/md7030401Marine-Derived Metabolites of S-Adenosylmethionine as Templates for New Anti-InfectivesJanice R. SufrinSteven FinckbeinerColin M. OliverS-Adenosylmethionine (AdoMet) is a key biochemical co-factor whose proximate metabolites include methylated macromolecules (e.g., nucleic acids, proteins, phospholipids), methylated small molecules (e.g., sterols, biogenic amines), polyamines (e.g., spermidine, spermine), ethylene, and N-acyl-homoserine lactones. Marine organisms produce numerous AdoMet metabolites whose novel structures can be regarded as lead compounds for anti-infective drug design. http://www.mdpi.com/1660-3397/7/3/401/adenosylmethionineethylenepolyaminesradical SAMquorum sensing |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Janice R. Sufrin Steven Finckbeiner Colin M. Oliver |
| spellingShingle |
Janice R. Sufrin Steven Finckbeiner Colin M. Oliver Marine-Derived Metabolites of S-Adenosylmethionine as Templates for New Anti-Infectives Marine Drugs adenosylmethionine ethylene polyamines radical SAM quorum sensing |
| author_facet |
Janice R. Sufrin Steven Finckbeiner Colin M. Oliver |
| author_sort |
Janice R. Sufrin |
| title |
Marine-Derived Metabolites of S-Adenosylmethionine as Templates for New Anti-Infectives |
| title_short |
Marine-Derived Metabolites of S-Adenosylmethionine as Templates for New Anti-Infectives |
| title_full |
Marine-Derived Metabolites of S-Adenosylmethionine as Templates for New Anti-Infectives |
| title_fullStr |
Marine-Derived Metabolites of S-Adenosylmethionine as Templates for New Anti-Infectives |
| title_full_unstemmed |
Marine-Derived Metabolites of S-Adenosylmethionine as Templates for New Anti-Infectives |
| title_sort |
marine-derived metabolites of s-adenosylmethionine as templates for new anti-infectives |
| publisher |
MDPI AG |
| series |
Marine Drugs |
| issn |
1660-3397 |
| publishDate |
2009-08-01 |
| description |
S-Adenosylmethionine (AdoMet) is a key biochemical co-factor whose proximate metabolites include methylated macromolecules (e.g., nucleic acids, proteins, phospholipids), methylated small molecules (e.g., sterols, biogenic amines), polyamines (e.g., spermidine, spermine), ethylene, and N-acyl-homoserine lactones. Marine organisms produce numerous AdoMet metabolites whose novel structures can be regarded as lead compounds for anti-infective drug design. |
| topic |
adenosylmethionine ethylene polyamines radical SAM quorum sensing |
| url |
http://www.mdpi.com/1660-3397/7/3/401/ |
| work_keys_str_mv |
AT janicersufrin marinederivedmetabolitesofsadenosylmethionineastemplatesfornewantiinfectives AT stevenfinckbeiner marinederivedmetabolitesofsadenosylmethionineastemplatesfornewantiinfectives AT colinmoliver marinederivedmetabolitesofsadenosylmethionineastemplatesfornewantiinfectives |
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