Marine-Derived Metabolites of S-Adenosylmethionine as Templates for New Anti-Infectives

Marine-Derived Metabolites of S-Adenosylmethionine as Templates for New Anti-Infectives

S-Adenosylmethionine (AdoMet) is a key biochemical co-factor whose proximate metabolites include methylated macromolecules (e.g., nucleic acids, proteins, phospholipids), methylated small molecules (e.g., sterols, biogenic amines), polyamines (e.g., spermidine, spermine), ethylene, and N-acyl-homose...

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Bibliographic Details
Main Authors: Janice R. Sufrin, Steven Finckbeiner, Colin M. Oliver
Format: Article
Language:English
Published: MDPI AG 2009-08-01
Series:Marine Drugs
Subjects:
adenosylmethionine
ethylene
polyamines
radical SAM
quorum sensing
Online Access:http://www.mdpi.com/1660-3397/7/3/401/
Description
Summary:S-Adenosylmethionine (AdoMet) is a key biochemical co-factor whose proximate metabolites include methylated macromolecules (e.g., nucleic acids, proteins, phospholipids), methylated small molecules (e.g., sterols, biogenic amines), polyamines (e.g., spermidine, spermine), ethylene, and N-acyl-homoserine lactones. Marine organisms produce numerous AdoMet metabolites whose novel structures can be regarded as lead compounds for anti-infective drug design.
ISSN:1660-3397

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