Lapsyn controls branch extension and positioning of astrocyte-like glia in the Drosophila optic lobe

Lapsyn controls branch extension and positioning of astrocyte-like glia in the Drosophila optic lobe

How glial cells, such as astrocytes, acquire their characteristic morphology during development is poorly understood. Here the authors describe the morphogenesis of astrocyte-like glia in the Drosophila optic lobe, and through a RNAi screen, they identify a transmembrane LRR protein–Lapsyn–that play...

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Main Authors: Benjamin Richier, Cristina de Miguel Vijandi, Stefanie Mackensen, Iris Salecker
Format: Article
Language:English
Published: Nature Publishing Group 2017-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-00384-z
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spelling doaj-4342d532fa0b49a2b9b04c6d9fd0ba932021-01-31T12:39:22ZengNature Publishing GroupNature Communications2041-17232017-08-018111710.1038/s41467-017-00384-zLapsyn controls branch extension and positioning of astrocyte-like glia in the Drosophila optic lobeBenjamin Richier0Cristina de Miguel Vijandi1Stefanie Mackensen2Iris Salecker3The Francis Crick Institute, Visual Circuit Assembly LaboratoryThe Francis Crick Institute, Visual Circuit Assembly LaboratoryThe Francis Crick Institute, Visual Circuit Assembly LaboratoryThe Francis Crick Institute, Visual Circuit Assembly LaboratoryHow glial cells, such as astrocytes, acquire their characteristic morphology during development is poorly understood. Here the authors describe the morphogenesis of astrocyte-like glia in the Drosophila optic lobe, and through a RNAi screen, they identify a transmembrane LRR protein–Lapsyn–that plays a critical role in this process.https://doi.org/10.1038/s41467-017-00384-z
collection DOAJ
language English
format Article
sources DOAJ
author Benjamin Richier
Cristina de Miguel Vijandi
Stefanie Mackensen
Iris Salecker
spellingShingle Benjamin Richier
Cristina de Miguel Vijandi
Stefanie Mackensen
Iris Salecker
Lapsyn controls branch extension and positioning of astrocyte-like glia in the Drosophila optic lobe
Nature Communications
author_facet Benjamin Richier
Cristina de Miguel Vijandi
Stefanie Mackensen
Iris Salecker
author_sort Benjamin Richier
title Lapsyn controls branch extension and positioning of astrocyte-like glia in the Drosophila optic lobe
title_short Lapsyn controls branch extension and positioning of astrocyte-like glia in the Drosophila optic lobe
title_full Lapsyn controls branch extension and positioning of astrocyte-like glia in the Drosophila optic lobe
title_fullStr Lapsyn controls branch extension and positioning of astrocyte-like glia in the Drosophila optic lobe
title_full_unstemmed Lapsyn controls branch extension and positioning of astrocyte-like glia in the Drosophila optic lobe
title_sort lapsyn controls branch extension and positioning of astrocyte-like glia in the drosophila optic lobe
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-08-01
description How glial cells, such as astrocytes, acquire their characteristic morphology during development is poorly understood. Here the authors describe the morphogenesis of astrocyte-like glia in the Drosophila optic lobe, and through a RNAi screen, they identify a transmembrane LRR protein–Lapsyn–that plays a critical role in this process.
url https://doi.org/10.1038/s41467-017-00384-z
work_keys_str_mv AT benjaminrichier lapsyncontrolsbranchextensionandpositioningofastrocytelikegliainthedrosophilaopticlobe
AT cristinademiguelvijandi lapsyncontrolsbranchextensionandpositioningofastrocytelikegliainthedrosophilaopticlobe
AT stefaniemackensen lapsyncontrolsbranchextensionandpositioningofastrocytelikegliainthedrosophilaopticlobe
AT irissalecker lapsyncontrolsbranchextensionandpositioningofastrocytelikegliainthedrosophilaopticlobe
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