Restoration of plasma kidney and liver biomarkers in doxorubicin-treated Wistar rats by aqueous extracts of Pleurotus tuberregium sclerotia and Cnidoscolus aconitifolius leaves

• Main Authors: Catherine Ikewuchi, Jude Ikewuchi, Mercy Ifeanacho
• Format: Article
• Language: English
• Published: Termedia Publishing House 2021-09-01
• Series: BioTechnologia
• Subjects: albumin/globulin ratio; alkaline phosphatase; blood urea nitrogen; creatinine; doxorubicin; trans¬aminases
• Online Access: https://www.termedia.pl/Restoration-of-plasma-kidney-and-liver-biomarkers-in-doxorubicin-treated-Wistar-rats-by-aqueous-extracts-of-Pleurotus-tuberregium-sclerotia-and-Cnidoscolus-aconitifolius-leaves,85,45041,1,1.html

The ability of aqueous extracts of sclerotia of Pleurotus tuberregium and leaves of Cnidoscolus aconitifolius to regulate plasma markers of kidney and liver function/integrity was investigated in doxorubicin-treated Wistar rats. Doxorubicin (dissolved in normal saline) was injected intraperitoneally (15 mg/kg body weight) into the rats; metformin was daily administered orally at 250 mg/kg, while the extracts were daily administered orally at doses of 50, 75, and 100 mg/kg. Compared to the test control, in both the doxorubicin pre-treatment (or ameliorative) study and the extract pre-treatment (protective) studies, the extracts and metformin-treated groups had significantly lower (P < 0.05) plasma levels of alkaline phosphatase, alanine transaminase and aspartate trans¬aminase, and concentrations of creatinine, urea, and blood urea nitrogen. However, the plasma globulin, albumin, and total protein concentrations and the albumin/globulin ratio of the extract and metformin-treated groups were significantly higher (P < 0.05). The extracts prevented (in the protective study) or attenuated (in the ameliorative study) doxorubicin-induced increase in the levels of plasma markers of kidney and liver function/integrity, and afforded protection or recovery towards near-normal values.