High-resolution X-ray structure of the trimeric Scar/WAVE-complex precursor Brk1.

High-resolution X-ray structure of the trimeric Scar/WAVE-complex precursor Brk1.

The Scar/WAVE-complex links upstream Rho-GTPase signaling to the activation of the conserved Arp2/3-complex. Scar/WAVE-induced and Arp2/3-complex-mediated actin nucleation is crucial for actin assembly in protruding lamellipodia to drive cell migration. The heteropentameric Scar/WAVE-complex is comp...

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Bibliographic Details
Main Authors:	Joern Linkner, Gregor Witte, Theresia Stradal, Ute Curth, Jan Faix
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2011-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC3119050?pdf=render

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