The effect of measurable and regular exercise on ovariectomized Sprague Dawley rats in improving skin quality

The decline of estrogen level causes various skin changes including amount of fibroblast, the thickness of epidermis and dermis. Physical exercise is believed can increase the estrogen level and give benefit impacts on skin. It mechanism is often associated with the increase of extragonadal aromatiz...

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Main Authors: Lutfi Nurdian Asnindari, Sri Kadarsih Soejono, . Hariyadi
Format: Article
Language:English
Published: Universitas Gadjah Mada 2018-10-01
Series:Journal of the Medical Sciences
Subjects:
Online Access:https://jurnal.ugm.ac.id/bik/article/view/32342
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spelling doaj-432f88555b964522b7814c4c4a0e90f92020-11-25T01:31:32ZengUniversitas Gadjah MadaJournal of the Medical Sciences0126-13122356-39312018-10-0150322221The effect of measurable and regular exercise on ovariectomized Sprague Dawley rats in improving skin qualityLutfi Nurdian Asnindari0Sri Kadarsih Soejono1. Hariyadi2Study Program of Master in Biomedical Sciences, Postgraduate Program of Faculty Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta,Department of Physiology, Faculty Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta,Department of Anatomic Pathology, Faculty Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, IndonesiaThe decline of estrogen level causes various skin changes including amount of fibroblast, the thickness of epidermis and dermis. Physical exercise is believed can increase the estrogen level and give benefit impacts on skin. It mechanism is often associated with the increase of extragonadal aromatization and estrogen serum, the activation of insulin-like growth factor (IGF), and the expression of estrogen receptor (ER). This study was conducted to investigate the effect of physical exercise in ovariectomized rat on the amount of fibroblast, the thickness of epidermis and dermis, the levels of ER β in skin and serum estrogen. Eight female Sprague Dawley rats aged 3 months were used in this study. Rats were divided into two groups i.e. Group 1 consisted of ovariectomized rats without physical exercise and Group 2 consisted of ovariectomized rats and given measurable and regular physical exercise. Rats ran on treadmill with the speed 18 m/min, the tilt of 5%, duration for 60 min/experiment/day, 5 times a week for 12 weeks. The amount of fibroblast, the thickness of epidermis and dermis, the levels of ERβ in skin and serum estrogen were measured after physical exercise. The result showed that there was a significant difference amount of fibroblast between group 1 and group 2 (p<0.05). However, no significant difference the levels of serum estrogen, ERβ, and the thickness of epidermis and dermis between Group 1 and Group 2 (p>0.05). There was a significant positive correlation between the level of serum estrogen and the thickness of epidermis (p<0.05), and negative correlation between the serum estrogen level and the level of ERβ (p<0.05), and negative significant correlation between the level of ERβ and the thickness of epidermis (p<0.05).  In conclusion, the amount of dermal fibroblast of ovariectomized rats increase after underwent measurable and regular exercise. There is correlation between the serum estrogen level and  the thickness of epidermis as well as ERβ.https://jurnal.ugm.ac.id/bik/article/view/32342physical exercise - serum estrogen - estrogen β receptor - fibroblast - dermis - epidermis.
collection DOAJ
language English
format Article
sources DOAJ
author Lutfi Nurdian Asnindari
Sri Kadarsih Soejono
. Hariyadi
spellingShingle Lutfi Nurdian Asnindari
Sri Kadarsih Soejono
. Hariyadi
The effect of measurable and regular exercise on ovariectomized Sprague Dawley rats in improving skin quality
Journal of the Medical Sciences
physical exercise - serum estrogen - estrogen β receptor - fibroblast - dermis - epidermis.
author_facet Lutfi Nurdian Asnindari
Sri Kadarsih Soejono
. Hariyadi
author_sort Lutfi Nurdian Asnindari
title The effect of measurable and regular exercise on ovariectomized Sprague Dawley rats in improving skin quality
title_short The effect of measurable and regular exercise on ovariectomized Sprague Dawley rats in improving skin quality
title_full The effect of measurable and regular exercise on ovariectomized Sprague Dawley rats in improving skin quality
title_fullStr The effect of measurable and regular exercise on ovariectomized Sprague Dawley rats in improving skin quality
title_full_unstemmed The effect of measurable and regular exercise on ovariectomized Sprague Dawley rats in improving skin quality
title_sort effect of measurable and regular exercise on ovariectomized sprague dawley rats in improving skin quality
publisher Universitas Gadjah Mada
series Journal of the Medical Sciences
issn 0126-1312
2356-3931
publishDate 2018-10-01
description The decline of estrogen level causes various skin changes including amount of fibroblast, the thickness of epidermis and dermis. Physical exercise is believed can increase the estrogen level and give benefit impacts on skin. It mechanism is often associated with the increase of extragonadal aromatization and estrogen serum, the activation of insulin-like growth factor (IGF), and the expression of estrogen receptor (ER). This study was conducted to investigate the effect of physical exercise in ovariectomized rat on the amount of fibroblast, the thickness of epidermis and dermis, the levels of ER β in skin and serum estrogen. Eight female Sprague Dawley rats aged 3 months were used in this study. Rats were divided into two groups i.e. Group 1 consisted of ovariectomized rats without physical exercise and Group 2 consisted of ovariectomized rats and given measurable and regular physical exercise. Rats ran on treadmill with the speed 18 m/min, the tilt of 5%, duration for 60 min/experiment/day, 5 times a week for 12 weeks. The amount of fibroblast, the thickness of epidermis and dermis, the levels of ERβ in skin and serum estrogen were measured after physical exercise. The result showed that there was a significant difference amount of fibroblast between group 1 and group 2 (p<0.05). However, no significant difference the levels of serum estrogen, ERβ, and the thickness of epidermis and dermis between Group 1 and Group 2 (p>0.05). There was a significant positive correlation between the level of serum estrogen and the thickness of epidermis (p<0.05), and negative correlation between the serum estrogen level and the level of ERβ (p<0.05), and negative significant correlation between the level of ERβ and the thickness of epidermis (p<0.05).  In conclusion, the amount of dermal fibroblast of ovariectomized rats increase after underwent measurable and regular exercise. There is correlation between the serum estrogen level and  the thickness of epidermis as well as ERβ.
topic physical exercise - serum estrogen - estrogen β receptor - fibroblast - dermis - epidermis.
url https://jurnal.ugm.ac.id/bik/article/view/32342
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