Autoreactive Peripheral Blood T Helper Cell Responses in Bullous Pemphigoid and Elderly Patients With Pruritic Disorders

Autoreactive Peripheral Blood T Helper Cell Responses in Bullous Pemphigoid and Elderly Patients With Pruritic Disorders

Bullous pemphigoid (BP) is a prototypic autoimmune disorder of the elderly, characterized by serum IgG autoantibodies, namely anti-BP180 and anti-BP230, directed against components of the basal membrane zone that lead to sub-epidermal loss of adhesion. Pruritus may be indicative of a pre-clinical st...

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Bibliographic Details
Main Authors: Dario Didona, Luca Scarsella, Milad Fehresti, Farzan Solimani, Hazem A. Juratli, Manuel Göbel, Stefan Mühlenbein, Lily Holiangu, Josquin Pieper, Vera Korff, Thomas Schmidt, Cassian Sitaru, Rüdiger Eming, Michael Hertl, Robert Pollmann
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
autoimmunity
pemphigoid
BP180
T cells
ELISpot assay
pruritus
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.569287/full

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