NMDA receptor antagonists attenuate intrathecal morphine-induced pruritus through ERK phosphorylation

NMDA receptor antagonists attenuate intrathecal morphine-induced pruritus through ERK phosphorylation

Abstract Pruritus is the most common complication of intrathecal morphine; however, its exact molecular mechanism is unclear, and treatment is challenging. The analgesic effect of N-methyl-D-aspartate (NMDA) receptor antagonists and the morphine-associated increase in NMDA receptor activation sugges...

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Bibliographic Details
Main Authors: Le Shen, Weijia Wang, Siyu Li, Jing Qin, Yuguang Huang
Format: Article
Language:English
Published: BMC 2018-06-01
Series:Molecular Brain
Subjects:
Intrathecal morphine
pruritus
analgesia
NMDA receptor antagonist
ERK
Online Access:http://link.springer.com/article/10.1186/s13041-018-0379-2

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