Nuclear microtubule filaments mediate non-linear directional motion of chromatin and promote DNA repair

Nuclear microtubule filaments mediate non-linear directional motion of chromatin and promote DNA repair

Following DNA damage, different processes come to action to aid repair. The authors here find that microtubule filaments within the cell nucleus capture and non-randomly mobilize damaged chromatin to mediate DNA repair.

Bibliographic Details
Main Authors: Roxanne Oshidari, Jonathan Strecker, Daniel K. C. Chung, Karan J. Abraham, Janet N. Y. Chan, Christopher J. Damaren, Karim Mekhail
Format: Article
Language:English
Published: Nature Publishing Group 2018-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-05009-7
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spelling doaj-4320e998628b46a9b1f9a18feb648d852021-05-11T10:09:31ZengNature Publishing GroupNature Communications2041-17232018-07-019111110.1038/s41467-018-05009-7Nuclear microtubule filaments mediate non-linear directional motion of chromatin and promote DNA repairRoxanne Oshidari0Jonathan Strecker1Daniel K. C. Chung2Karan J. Abraham3Janet N. Y. Chan4Christopher J. Damaren5Karim Mekhail6Department of Laboratory Medicine and Pathobiology, MaRS Centre, University of TorontoDepartment of Molecular Genetics, MaRS Centre, University of TorontoDepartment of Laboratory Medicine and Pathobiology, MaRS Centre, University of TorontoDepartment of Laboratory Medicine and Pathobiology, MaRS Centre, University of TorontoDepartment of Laboratory Medicine and Pathobiology, MaRS Centre, University of TorontoInstitute for Aerospace Studies, University of TorontoDepartment of Laboratory Medicine and Pathobiology, MaRS Centre, University of TorontoFollowing DNA damage, different processes come to action to aid repair. The authors here find that microtubule filaments within the cell nucleus capture and non-randomly mobilize damaged chromatin to mediate DNA repair.https://doi.org/10.1038/s41467-018-05009-7
collection DOAJ
language English
format Article
sources DOAJ
author Roxanne Oshidari
Jonathan Strecker
Daniel K. C. Chung
Karan J. Abraham
Janet N. Y. Chan
Christopher J. Damaren
Karim Mekhail
spellingShingle Roxanne Oshidari
Jonathan Strecker
Daniel K. C. Chung
Karan J. Abraham
Janet N. Y. Chan
Christopher J. Damaren
Karim Mekhail
Nuclear microtubule filaments mediate non-linear directional motion of chromatin and promote DNA repair
Nature Communications
author_facet Roxanne Oshidari
Jonathan Strecker
Daniel K. C. Chung
Karan J. Abraham
Janet N. Y. Chan
Christopher J. Damaren
Karim Mekhail
author_sort Roxanne Oshidari
title Nuclear microtubule filaments mediate non-linear directional motion of chromatin and promote DNA repair
title_short Nuclear microtubule filaments mediate non-linear directional motion of chromatin and promote DNA repair
title_full Nuclear microtubule filaments mediate non-linear directional motion of chromatin and promote DNA repair
title_fullStr Nuclear microtubule filaments mediate non-linear directional motion of chromatin and promote DNA repair
title_full_unstemmed Nuclear microtubule filaments mediate non-linear directional motion of chromatin and promote DNA repair
title_sort nuclear microtubule filaments mediate non-linear directional motion of chromatin and promote dna repair
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-07-01
description Following DNA damage, different processes come to action to aid repair. The authors here find that microtubule filaments within the cell nucleus capture and non-randomly mobilize damaged chromatin to mediate DNA repair.
url https://doi.org/10.1038/s41467-018-05009-7
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AT jonathanstrecker nuclearmicrotubulefilamentsmediatenonlineardirectionalmotionofchromatinandpromotednarepair
AT danielkcchung nuclearmicrotubulefilamentsmediatenonlineardirectionalmotionofchromatinandpromotednarepair
AT karanjabraham nuclearmicrotubulefilamentsmediatenonlineardirectionalmotionofchromatinandpromotednarepair
AT janetnychan nuclearmicrotubulefilamentsmediatenonlineardirectionalmotionofchromatinandpromotednarepair
AT christopherjdamaren nuclearmicrotubulefilamentsmediatenonlineardirectionalmotionofchromatinandpromotednarepair
AT karimmekhail nuclearmicrotubulefilamentsmediatenonlineardirectionalmotionofchromatinandpromotednarepair
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