Display of GPI-anchored anti-EGFR nanobodies on extracellular vesicles promotes tumour cell targeting

Display of GPI-anchored anti-EGFR nanobodies on extracellular vesicles promotes tumour cell targeting

Background: Extracellular vesicles (EVs) are attractive candidate drug delivery systems due to their ability to functionally transport biological cargo to recipient cells. However, the apparent lack of target cell specificity of exogenously administered EVs limits their therapeutic applicability. In...

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Bibliographic Details
Main Authors: Sander A. A. Kooijmans, Clara Gómez Aleza, Steve R. Roffler, Wouter W. van Solinge, Pieter Vader, Raymond M. Schiffelers
Format: Article
Language:English
Published: Taylor & Francis Group 2016-03-01
Series:Journal of Extracellular Vesicles
Subjects:
extracellular vesicles
nanobody
lipid raft
glycosylphosphatidylinositol anchor
targeting
drug delivery
epidermal growth factor receptor
perfusion
exosomes
Online Access:http://www.journalofextracellularvesicles.net/index.php/jev/article/view/31053/pdf_48

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http://www.journalofextracellularvesicles.net/index.php/jev/article/view/31053/pdf_48

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