The Use of Chemical-Chemical Interaction and Chemical Structure to Identify New Candidate Chemicals Related to Lung Cancer.

The Use of Chemical-Chemical Interaction and Chemical Structure to Identify New Candidate Chemicals Related to Lung Cancer.

Lung cancer causes over one million deaths every year worldwide. However, prevention and treatment methods for this serious disease are limited. The identification of new chemicals related to lung cancer may aid in disease prevention and the design of more effective treatments. This study employed a...

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Main Authors: Lei Chen, Jing Yang, Mingyue Zheng, Xiangyin Kong, Tao Huang, Yu-Dong Cai
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0128696
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spelling doaj-4311016191974476b825b6e1607cfc182021-03-03T20:02:44ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01106e012869610.1371/journal.pone.0128696The Use of Chemical-Chemical Interaction and Chemical Structure to Identify New Candidate Chemicals Related to Lung Cancer.Lei ChenJing YangMingyue ZhengXiangyin KongTao HuangYu-Dong CaiLung cancer causes over one million deaths every year worldwide. However, prevention and treatment methods for this serious disease are limited. The identification of new chemicals related to lung cancer may aid in disease prevention and the design of more effective treatments. This study employed a weighted network, constructed using chemical-chemical interaction information, to identify new chemicals related to two types of lung cancer: non-small lung cancer and small-cell lung cancer. Then, a randomization test as well as chemical-chemical interaction and chemical structure information were utilized to make further selections. A final analysis of these new chemicals in the context of the current literature indicates that several chemicals are strongly linked to lung cancer.https://doi.org/10.1371/journal.pone.0128696
collection DOAJ
language English
format Article
sources DOAJ
author Lei Chen
Jing Yang
Mingyue Zheng
Xiangyin Kong
Tao Huang
Yu-Dong Cai
spellingShingle Lei Chen
Jing Yang
Mingyue Zheng
Xiangyin Kong
Tao Huang
Yu-Dong Cai
The Use of Chemical-Chemical Interaction and Chemical Structure to Identify New Candidate Chemicals Related to Lung Cancer.
PLoS ONE
author_facet Lei Chen
Jing Yang
Mingyue Zheng
Xiangyin Kong
Tao Huang
Yu-Dong Cai
author_sort Lei Chen
title The Use of Chemical-Chemical Interaction and Chemical Structure to Identify New Candidate Chemicals Related to Lung Cancer.
title_short The Use of Chemical-Chemical Interaction and Chemical Structure to Identify New Candidate Chemicals Related to Lung Cancer.
title_full The Use of Chemical-Chemical Interaction and Chemical Structure to Identify New Candidate Chemicals Related to Lung Cancer.
title_fullStr The Use of Chemical-Chemical Interaction and Chemical Structure to Identify New Candidate Chemicals Related to Lung Cancer.
title_full_unstemmed The Use of Chemical-Chemical Interaction and Chemical Structure to Identify New Candidate Chemicals Related to Lung Cancer.
title_sort use of chemical-chemical interaction and chemical structure to identify new candidate chemicals related to lung cancer.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2015-01-01
description Lung cancer causes over one million deaths every year worldwide. However, prevention and treatment methods for this serious disease are limited. The identification of new chemicals related to lung cancer may aid in disease prevention and the design of more effective treatments. This study employed a weighted network, constructed using chemical-chemical interaction information, to identify new chemicals related to two types of lung cancer: non-small lung cancer and small-cell lung cancer. Then, a randomization test as well as chemical-chemical interaction and chemical structure information were utilized to make further selections. A final analysis of these new chemicals in the context of the current literature indicates that several chemicals are strongly linked to lung cancer.
url https://doi.org/10.1371/journal.pone.0128696
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