Clinical Significance of Variants in the TTN Gene in a Large Cohort of Patients With Sporadic Dilated Cardiomyopathy

Clinical Significance of Variants in the TTN Gene in a Large Cohort of Patients With Sporadic Dilated Cardiomyopathy

Background: Mutations in the TTN gene are the most common causes of dilated cardiomyopathy (DCM). The clinical significance of TTN gene variants remains inadequately understood.Methods: Whole-exome sequencing and phenotypic characterisation were performed, and patients were followed up for a median...

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Bibliographic Details
Main Authors: Lei Xiao, Chenze Li, Yang Sun, Yanghui Chen, Haoran Wei, Dong Hu, Ting Yu, Xianqing Li, Li Jin, Leming Shi, Ali J. Marian, Dao Wen Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
DCM
TTN
genetics
phenotype
prognosis
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2021.657689/full

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