68Ga-DOTATATE PET/CT Compared with 131I-MIBG SPECT/CT in the Evaluation of Neural Crest Tumors
<strong><em>Objective(s):</em></strong> <sup>68</sup>Ga-DOTATATE positron emission tomography (PET)/computed tomography (CT) has shown promising results in imaging of neural crest tumors (NCT). Herein, we compared the performance of <sup>68</sup>Ga-DOT...
Main Authors: | , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Mashhad University of Medical Sciences
2020-01-01
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Series: | Asia Oceania Journal of Nuclear Medicine and Biology |
Subjects: | |
Online Access: | http://aojnmb.mums.ac.ir/article_14215_f10a5482f029999be216e865dfd8b6b6.pdf |
Summary: | <strong><em>Objective(s):</em></strong> <sup>68</sup>Ga-DOTATATE positron emission tomography (PET)/computed tomography (CT) has shown promising results in imaging of neural crest tumors (NCT). Herein, we compared the performance of <sup>68</sup>Ga-DOTATATE PET/CT and <sup>131</sup>I-MIBG single photon emission computed tomography (SPECT)/CT in the initial diagnosis, staging and follow-up of patients with NCTs.<br /> <strong><em>Methods: </em></strong>Twenty-five patients (males:females=8:17; age range=2–71 years) with clinically proven or suspicious neuroblastoma, pheochromocytoma (PCC) or paraganglioma (PGL) were enrolled in this prospective study and underwent both <sup>68</sup>Ga-DOTATATE PET/CT and <sup>131</sup>I-MIBG SPECT/CT. A composite reference standard derived from histopathological information, together with anatomical and functional imaging findings, was used to validate the results. Imaging findings were assessed on a per-patient and on a per-lesion basis. Sensitivity and accuracy were assessed using McNemar’s test.<br /> <strong><em>R</em></strong><strong><em>esults</em></strong><em>: </em>Referring to radiological imaging and histopathological findings as reference standard, <sup>68</sup>Ga-DOTATATE and <sup>131</sup>I-MIBG scans showed a sensitivity and accuracy of (100%, 96%) and (86.7%, 88%), respectively, on a per-patient basis. In PCC/PGL patients, on a per-patient basis, the sensitivity of <sup>68</sup>Ga-DOTATATE was 100% and that of <sup>131</sup>I-MIBG was 77.8%. In neuroblastoma patients, on a per-patient basis, the sensitivities of both <sup>68</sup>Ga-DOTATATE and <sup>131</sup>I-MIBG were 100%. Overall, in this patient cohort, <sup>68</sup>Ga-DOTATATE PET/CT identified 52 lesions and <sup>131</sup>I-MIBG SPECT/CT identified only 30 lesions. On a per-lesion analysis, <sup>68</sup>Ga-DOTATATE was found to be superior to <sup>131</sup>I-MIBG in detecting lesions in all anatomical locations, particularly osseous lesions. According to the McNemar test results, differences were not statistically significant.<br /> <strong><em>Conclusion: </em></strong>This relatively small patient cohort suggests <sup>68</sup>Ga-DOTATATE PET/CT be superior to <sup>131</sup>I-MIBG SPECT/CT in providing particularly valuable information for both primary staging and follow-up in patients with NCT. |
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ISSN: | 2322-5718 2322-5726 |