Polydatin improves osteogenic differentiation of human bone mesenchymal stem cells by stimulating TAZ expression via BMP2-Wnt/β-catenin signaling pathway

Polydatin improves osteogenic differentiation of human bone mesenchymal stem cells by stimulating TAZ expression via BMP2-Wnt/β-catenin signaling pathway

Abstract Objectives Polydatin (PD), extracted from Polygonum cuspidatum, has shown potential therapeutic applications due to its antiosteoporotic and anti-inflammatory activities. Our previous study suggested that PD promotes the osteogenesis of human bone marrow stromal cells (hBMSCs) via the BMP2-...

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Bibliographic Details
Main Authors: Ying-Shan Shen, Xiao-Jun Chen, Sha-Na Wuri, Fan Yang, Feng-Xiang Pang, Liang-Liang Xu, Wei He, Qiu-Shi Wei
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Stem Cell Research & Therapy
Subjects:
Polydatin
Human bone marrow stromal cells
Osteogenic differentiation
Transcriptional coactivator with PDZ-binding motif
Online Access:http://link.springer.com/article/10.1186/s13287-020-01705-8

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http://link.springer.com/article/10.1186/s13287-020-01705-8

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