Dchs1–Fat4 regulation of polarized cell behaviours during skeletal morphogenesis

How the shape of the sternum is regulated is unclear. Here, the authors identify the Dchs1-Fat4-planar cell polarity pathway as controlling cell orientation and cell intercalation of mesenchymal cells that form skeletal condensations for the mouse sternum, which defines the relative dimensions of th...

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Bibliographic Details
Main Authors: Yaopan Mao, Anna Kuta, Ivan Crespo-Enriquez, Danielle Whiting, Tina Martin, Joanna Mulvaney, Kenneth D. Irvine, Philippa Francis-West
Format: Article
Language:English
Published: Nature Publishing Group 2016-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms11469