Research Progress on the Mechanism of Mitochondrial Autophagy in Cerebral Stroke

Research Progress on the Mechanism of Mitochondrial Autophagy in Cerebral Stroke

Mitochondrial autophagy is an early defense and protection process that selectively clears dysfunctional or excessive mitochondria through a distinctive mechanism to maintain intracellular homeostasis. Mitochondrial dysfunction during cerebral stroke involves metabolic disbalance, oxidative stress,...

Full description

Bibliographic Details
Main Authors: Li Lei, Shuaifeng Yang, Xiaoyang Lu, Yongfa Zhang, Tao Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Aging Neuroscience
Subjects:
mitochondrial autophagy
PINK1/Parkin
FUNDC1
NIX/BNIP3
cerebral stroke
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2021.698601/full
id doaj-42e4ed9a0ee9476580ba41a9c7bd4993
record_format Article
spelling doaj-42e4ed9a0ee9476580ba41a9c7bd49932021-07-15T11:33:09ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652021-07-011310.3389/fnagi.2021.698601698601Research Progress on the Mechanism of Mitochondrial Autophagy in Cerebral StrokeLi Lei0Shuaifeng Yang1Xiaoyang Lu2Yongfa Zhang3Tao Li4Department of Neurosurgery, The First People’s Hospital of Yunnan Province (Kunhua Hospital/The Affiliated Hospital of Kunming University of Science and Technology), Kunming, ChinaDepartment of Neurosurgery, The First People’s Hospital of Yunnan Province (Kunhua Hospital/The Affiliated Hospital of Kunming University of Science and Technology), Kunming, ChinaTranslational Neurosurgery and Neurobiology, University Hospital Aachen, RWTH Aachen, Aachen, GermanyDepartment of Neurosurgery, The First People’s Hospital of Yunnan Province (Kunhua Hospital/The Affiliated Hospital of Kunming University of Science and Technology), Kunming, ChinaDepartment of Neurosurgery, The First People’s Hospital of Yunnan Province (Kunhua Hospital/The Affiliated Hospital of Kunming University of Science and Technology), Kunming, ChinaMitochondrial autophagy is an early defense and protection process that selectively clears dysfunctional or excessive mitochondria through a distinctive mechanism to maintain intracellular homeostasis. Mitochondrial dysfunction during cerebral stroke involves metabolic disbalance, oxidative stress, apoptosis, endoplasmic reticulum stress, and abnormal mitochondrial autophagy. This article reviews the research progress on the mechanism of mitochondrial autophagy in ischemic stroke to provide a theoretical basis for further research on mitochondrial autophagy and the treatment of ischemic stroke.https://www.frontiersin.org/articles/10.3389/fnagi.2021.698601/fullmitochondrial autophagyPINK1/ParkinFUNDC1NIX/BNIP3cerebral stroke
collection DOAJ
language English
format Article
sources DOAJ
author Li Lei
Shuaifeng Yang
Xiaoyang Lu
Yongfa Zhang
Tao Li
spellingShingle Li Lei
Shuaifeng Yang
Xiaoyang Lu
Yongfa Zhang
Tao Li
Research Progress on the Mechanism of Mitochondrial Autophagy in Cerebral Stroke
Frontiers in Aging Neuroscience
mitochondrial autophagy
PINK1/Parkin
FUNDC1
NIX/BNIP3
cerebral stroke
author_facet Li Lei
Shuaifeng Yang
Xiaoyang Lu
Yongfa Zhang
Tao Li
author_sort Li Lei
title Research Progress on the Mechanism of Mitochondrial Autophagy in Cerebral Stroke
title_short Research Progress on the Mechanism of Mitochondrial Autophagy in Cerebral Stroke
title_full Research Progress on the Mechanism of Mitochondrial Autophagy in Cerebral Stroke
title_fullStr Research Progress on the Mechanism of Mitochondrial Autophagy in Cerebral Stroke
title_full_unstemmed Research Progress on the Mechanism of Mitochondrial Autophagy in Cerebral Stroke
title_sort research progress on the mechanism of mitochondrial autophagy in cerebral stroke
publisher Frontiers Media S.A.
series Frontiers in Aging Neuroscience
issn 1663-4365
publishDate 2021-07-01
description Mitochondrial autophagy is an early defense and protection process that selectively clears dysfunctional or excessive mitochondria through a distinctive mechanism to maintain intracellular homeostasis. Mitochondrial dysfunction during cerebral stroke involves metabolic disbalance, oxidative stress, apoptosis, endoplasmic reticulum stress, and abnormal mitochondrial autophagy. This article reviews the research progress on the mechanism of mitochondrial autophagy in ischemic stroke to provide a theoretical basis for further research on mitochondrial autophagy and the treatment of ischemic stroke.
topic mitochondrial autophagy
PINK1/Parkin
FUNDC1
NIX/BNIP3
cerebral stroke
url https://www.frontiersin.org/articles/10.3389/fnagi.2021.698601/full
work_keys_str_mv AT lilei researchprogressonthemechanismofmitochondrialautophagyincerebralstroke
AT shuaifengyang researchprogressonthemechanismofmitochondrialautophagyincerebralstroke
AT xiaoyanglu researchprogressonthemechanismofmitochondrialautophagyincerebralstroke
AT yongfazhang researchprogressonthemechanismofmitochondrialautophagyincerebralstroke
AT taoli researchprogressonthemechanismofmitochondrialautophagyincerebralstroke
_version_ 1721301025546043392

Similar Items