A Tripartite Interaction Among the Calcium Channel α1- and β-Subunits and F-Actin Increases the Readily Releasable Pool of Vesicles and Its Recovery After Depletion

A Tripartite Interaction Among the Calcium Channel α1- and β-Subunits and F-Actin Increases the Readily Releasable Pool of Vesicles and Its Recovery After Depletion

Neurotransmitter release is initiated by the influx of Ca2+via voltage-gated calcium channels. The accessory β-subunit (CaVβ) of these channels shapes synaptic transmission by associating with the pore-forming subunit (CaVα1) and up-regulating presynaptic calcium currents. Besides CaVα1, CaVβ intera...

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Bibliographic Details
Main Authors: Gustavo A. Guzman, Raul E. Guzman, Nadine Jordan, Patricia Hidalgo
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Cellular Neuroscience
Subjects:
calcium channel
CaVβ subunits
F-actin
RRP size
RRP refilling
EPSC
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00125/full

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