| Summary: | A case report to describe the occurrence of Dupuytren's disease in the wrist leading to compression of the palmar cutaneous branch of the median nerve. A 60-year-old male presented with a lump on the volar aspect of the left wrist with reduced sensation in the thenar eminence. Intra-operatively this was found to be a nodule integrated within the palmaris longus tendon and positioned superficially to the palmar cutaneous branch of the median nerve. Histological findings were consistent with Dupuytren's disease and the patient's symptoms improved post excision of the nodule. Although Dupuytren's nodules occur rarely in the wrist, they should be considered as part of the differential diagnosis of wrist lumps and they have the potential to impact on nearby neural structures. Keywords: Dupuytren's disease, Wrist, Nerve compression, Palmaris longus, Palmar cutaneous branch of the median nerve
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