Molecular Dynamics Simulations of a Chimeric Androgen Receptor Protein (SPARKI) Confirm the Importance of the Dimerization Domain on DNA Binding Specificity

Molecular Dynamics Simulations of a Chimeric Androgen Receptor Protein (SPARKI) Confirm the Importance of the Dimerization Domain on DNA Binding Specificity

The DNA binding domains of Androgen/Glucocorticoid receptors (AR/GR), members of class I steroid receptors, bind as a homo-dimer to a cis-regulatory element. These response elements are arranged as inverted repeat (IR) of hexamer “AGAACA”, separated with a 3 base pairs spacer. DNA binding domains of...

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Bibliographic Details
Main Authors: Mahdi Bagherpoor Helabad, Senta Volkenandt, Petra Imhof
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Molecular Biosciences
Subjects:
androgen receptor
glucocorticoid receptor
response element
protein-DNA interaction
chimeric SPARKI protein
Online Access:https://www.frontiersin.org/article/10.3389/fmolb.2020.00004/full

Internet

https://www.frontiersin.org/article/10.3389/fmolb.2020.00004/full

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